日常的な放射線被ばくは、体内の細胞に少しずつ損傷を与え、私たちを老化に導きます。私たちは、幹細胞技術と光学技術を用いて放射線が健康に与える影響を調べて、安全に放射線を恐れるための提言を目指します。また、日々の研究から生まれる技術の社会実装も実施し、放射線医科学研究からコスメ業界や漁業への貢献を目指します。

学生実習（基礎配属）の学生が中心の小さな研究室ですが、その分、気を使うことも少なく笑顔にあふれています。研究者を目指す学生、起業を目指す学生、日々釣りを楽しみたい学生、広くお待ちしております。

2024

Watanabe TM, Ueda S, Ishida S, Shioi G, Kaneshiro J, Magari M. Optical evaluation of internal damage to human hair based on second near-infrared window polarization microscopy. Int J Cosmet Sci. 2024 May 27. doi: 10.1111/ics.12970.

Fujita H, Haruki T, Sudo K, Koga Y, Kakamura Y, Abe K, Yoshida Y, Koizumi K, Watanabe TM. Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing. Biophys Physicobiol. Special Issue: Singularity Biology and Beyond, e211016 (2024) doi: 10.2142/biophysico.bppb-v21.s016.

Ichinose J, Oba K, Arase Y, Kaneshiro J, Tate SI, Watanabe TM. Quantitative prediction of rice starch digestibility using Raman spectroscopy and multivariate calibration analysis. Food Chem. 2024 Mar 1;435:137505. doi: 10.1016/j.foodchem.2023.137505.

2023

Okamoto K, Fujita H, Okada Y, Shinkai S, Onami S, Abe K, Fujimoto K, Sasaki K, Shioi G, Watanabe TM. Single-molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance. EMBO J. 2023 Sep 18;42(18):e112305. doi: 10.15252/embj.2022112305.

Fujita H, Kaneshiro J, Takeda M, Sasaki K, Yamamoto R, Umetsu D, Kuranaga E, Higo S, Kondo T, Asano Y, Sakata Y, Miyagawa S, Watanabe TM. Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation. Life Sci Alliance. 2023 May 26;6(7):e202302070. doi: 10.26508/lsa.202302070.

2022

Haruki T, Yonezawa S, Koizumi K, Yoshida Y, Watanabe TM, Fujita H, Oshima Y, Oku M, Taketani A, Yamazaki M, Ichimura T, Kadowaki M, Kitajima I, Saito S. Application of the Dynamical Network Biomarker Theory to Raman Spectra. Biomolecules. 2022 Nov 22;12(12):1730. doi: 10.3390/biom12121730.

Watanabe TM, Sasaki K, Fujita H. Recent Advances in Raman Spectral Imaging in Cell Diagnosis and Gene Expression Prediction. Genes (Basel). 2022 Nov 16;13(11):2127. doi: 10.3390/genes13112127.

Kashimoto R, Furukawa S, Yamamoto S, Kamei Y, Sakamoto J, Nonaka S, Watanabe TM, Sakamoto T, Sakamoto H, Satoh A. Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration. iScience. 2022 Jun 3;25(7):104524. doi: 10.1016/j.isci.2022.104524.

Yasuda K, Watanabe TM, Kang MG, Seo JK, Rhee HW, Tate SI. Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations. FEBS Lett. 2022 Jun;596(11):1412-1423. doi: 10.1002/1873-3468.14353.

Sato O, Sakai T, Choo YY, Ikebe R, Watanabe TM, Ikebe M. Mitochondria-associated myosin 19 processively transports mitochondria on actin tracks in living cells. J Biol Chem. 2022 May;298(5):101883. doi: 10.1016/j.jbc.2022.101883.

2021

Kaneshiro J, Shioi G, Okamoto K, Onami S, Watanabe TM. Improvement in image quality via the pseudo confocal effect in multidirectional digital scanned laser light-sheet microscopy. Opt Express. 2021 Jul 19;29(15):24278-24288. doi: 10.1364/OE.423783.

Ichimura T, Kakizuka T, Horikawa K, Seiriki K, Kasai A, Hashimoto H, Fujita K, Watanabe TM, Nagai T. Exploring rare cellular activity in more than one million cells by a transscale scope. Sci Rep. 2021 Aug 16;11(1):16539. doi: 10.1038/s41598-021-95930-7.

Okamoto K, Watanabe TM, Horie M, Nishiyama M, Harada Y, Fujita H. Pressure-induced changes on the morphology and gene expression in mammalian cells. Biol Open. 2021 Jul 15;10(7):bio058544. doi: 10.1242/bio.058544.

Morikawa TJ, Nishiyama M, Yoshizawa K, Fujita H, Watanabe TM. Glycine insertion modulates the fluorescence properties of Aequorea victoria green fluorescent protein and its variants in their ambient environment. Biophys Physicobiol. 2021 May 21;18:145-158. doi: 10.2142/biophysico.bppb-v18.016.

Machiyama H, Yamaguchi T, Watanabe TM, Yanagida T, Fujita H. Activation probability of a single naïve T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell. FEBS Lett. 2021 Jun;595(11):1512-1524. doi: 10.1002/1873-3468.14082.

Kawai T, Mihara Y, Morita M, Ohkubo M, Asami T, Watanabe TM. Quantitation of Cell Membrane Permeability of Cyclic Peptides by Single-Cell Cytoplasm Mass Spectrometry. Anal Chem. 2021 Feb 23;93(7):3370-3377. doi: 10.1021/acs.analchem.0c03901.

2020

Naka K, Ochiai R, Matsubara E, Kondo C, Yang KM, Hoshii T, Araki M, Araki K, Sotomaru Y, Sasaki K, Mitani K, Kim DW, Ooshima A, Kim SJ. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2020 Sep 17;11(1):4681. doi: 10.1038/s41467-020-18491-9.

Panina Y, Germond A, Watanabe TM. Analysis of the stability of 70 housekeeping genes during iPS reprogramming. Sci Rep. 2020 Dec 10;10(1):21711. doi: 10.1038/s41598-020-78863-5.

Germond A, Panina Y, Shiga M, Niioka H, Watanabe TM. Following Embryonic Stem Cells, Their Differentiated Progeny, and Cell-State Changes During iPS Reprogramming by Raman Spectroscopy. Anal Chem. 2020 Nov 17;92(22):14915-14923. doi: 10.1021/acs.analchem.0c01800.

Mizushima R, Inoue K, Fujiwara H, Iwane AH, Watanabe TM, Kimura A. Multiplexed 129Xe HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells. Contrast Media Mol Imaging. 2020 Mar 12;2020:5425934. doi: 10.1155/2020/5425934.

Kakizuka T , Takai A , Yoshizawa K , Okada Y , Watanabe TM . An improved fluorescent protein-based expression reporter system that utilizes bioluminescence resonance energy transfer and peptide-assisted complementation. Chem Commun (Camb). 2020 Mar 28;56(25):3625-3628. doi: 10.1039/c9cc08664a.